RT Journal Article
SR Electronic
T1 Fractional exhaled nitric oxide in bronchiectasis
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP P2214
VO 40
IS Suppl 56
A1 Young-Jae Cho
A1 Hyo-Jeong Lim
A1 Jong Sun Park
A1 Sei Won Lee
A1 Jae Ho Lee
A1 Choon-Taek Lee
A1 Ho Il Yoon
YR 2012
UL http://erj.ersjournals.com/content/40/Suppl_56/P2214.abstract
AB Fractional exhaled nitric oxide (FeNO) can be measured easily, rapidly, and noninvasively for assessment of airway inflammation, especially mediated by eosinophil, such as asthma. In bronchiectasis, the pathogenesis has been known as chronic airway inflammation and infection with abnormal airway dilatation; however, there are little studies to evaluate the clinical application of exhaled nitric oxide in bronchiectasis.From March 2010 to September 2011, 30 patients with bronchiectasis diagnosed by chest high resolution CT performed FeNO, compared with various pulmonary diseases, including asthma (n=24), COPD (n=21) and other infectious diseases (n=25). All patients carried out eosinophil count with chemistry, simple radiograph, sputum examination and spirometry, if indicated.FeNO (mean, ppb) in patients with bronchiectasis was 19.1, compared to 68.4, 31.7 and 18.9 in asthma, COPD and other infectious diseases, respectively. FeNO in bronchiectasis was significantly lower than asthma (P<0.001), however, no statistical differences were seen between bronchiectasis and other pulmonary diseases except asthma. No correlation of FeNO with eosinophil count in bronchiectasis was seen, despite the correlation was true in all of patients enrolled in study. FeNO in bronchiectasis with co-infection of nonmycobacterium tuberculosis was slightly lower than without co-infection (14.8 vs. 20.8). FeNO also tended to decrease along with multi-lobe involvements on CT.FeNO in bronchiectasis was lower than other respiratory diseases, especially compared with asthma. Clinical application of FeNO to bronchiectasis might be considered in the subgroup by clinical situation.