TY - JOUR T1 - Arterial stiffness and endothelial dysfunction in stable COPD patients JF - European Respiratory Journal JO - Eur Respir J VL - 40 IS - Suppl 56 SP - P220 AU - Marina Makarova AU - Sergey Avdeev AU - Alexander Chuchalin Y1 - 2012/09/01 UR - http://erj.ersjournals.com/content/40/Suppl_56/P220.abstract N2 - Cardiovascular disease is common in COPD patients and is associated with poorer prognosis. Arterial stiffness (AS) is a validated measure of cardiovascular risk.Aim: To assess AS and endothelial dysfunction (ED) in COPD patients, to determine thier association with other clinical and cardiopulmonary functional parameters.Methods: We enrolled 41 COPD patients (64.5±7.6 yrs, FEV1 37.7±14.1%) and 34 normal control subjects (CS). Lung function, blood gases, six-minute walking distance (6MWD), nocturnal pulseoximetry, serum C-reactive protein (CRP) were measured. Assessment of AS was performed by use of digital photoplethysmography (Pulse Trace PCA 2 Micro Medical). Change in reflection index (RI) of the digital volume pulse in response to salbutamol (RISALB) and serum endotelin-1 (ET-1) were used to assess ED.Results: In COPD patients stiffness index (SI) was higher than in CS: 11.3±3.3 vs 6.9±0.9 m/s, p<0.05. There were significant correlations of SI with FEV1 (r= 0.40), respiratory rate (r=0.44), BMI (r=-0.53), 6MWD (r=-0.53), pulse during sleep (r=0.50), CRP (r=0.47). RISALB was lower in COPD patients than in CS (1,15[0-10]% vs 11,50[6-19]%, p<0,05) and decreased according to COPD stages: GOLD II 5,85[2,15-13]%; GOLD III 1,65[-1,7-10,35]%; GOLD IV 0[0-2]%; p>0,05. The ET-1 levels were elevated in COPD patients and correlated with RISALB (r=-0.46, p=0.03). RISALB was significantly associated with mean nocturnal SpO2 (r=0.38), DLCO (r=0.45).Conclusion: AS and ED are significantly impaired in COPD patients. Decreased FEV1, 6MWD and systemic inflammation were associated with ED. Hypoxemia, elevated ET-1 level and decreased DLCO have an association with both AS and ED. ER -