PT  - JOURNAL ARTICLE
AU  - Helder Novais e Bastos
AU  - Patrícia Mota
AU  - Natália Melo
AU  - Marília Beltrão
AU  - Oksana Sokhatska
AU  - Carmo Palmares
AU  - António Morais
TI  - Pulmonary eosinophilic syndromes characterization. The role of peripheral eosinophilia as a marker of clinical evolution
DP  - 2012 Sep 01
TA  - European Respiratory Journal
PG  - P3649
VI  - 40
IP  - Suppl 56
4099  - http://erj.ersjournals.com/content/40/Suppl_56/P3649.short
4100  - http://erj.ersjournals.com/content/40/Suppl_56/P3649.full
SO  - Eur Respir J2012 Sep 01; 40
AB  - INTRODUCTION: Pulmonary eosinophilic syndromes (ES) are a heterogeneous, rare and not fully characterized group of diseases. OBJECTIVES: Evaluation of ES patient's clinical features and its evolution. METHODS: 47 patients with >20% BAL eosinophils or compatible histological features were included and its clinical files retrospectively analyzed. RESULTS: After excluding 19 patients that had other diseases and 9 because of lacking information, 19 patients were enrolled: 8 presented Chronic Eosinophilic Pneumonia (CEP), 6 Churg-Strauss Syndrome (CSS), 3 Acute Eosinophilic Pneumonia and 2 Allergic Bronchopulmonary Aspergillosis (ABPA). Mean age at symptoms onset 37±14.6 and at diagnosis 43±14.3 years. The majority was female (68.4%) and nonsmokers (76.5%). Peripheral eosinophilia was observed in 78.9% patients (1.73±1.32x109/L), mean eosinophilia in BAL was 51.1±29.16%, airflow obstruction was observed in 55.6% patients, 22.2% had restrictive pattern, 16.7% mixed pattern and 5.6% normal values, without significant differences among entities. Concerning CEP, CSS and ABPA cases after treatment, 83.3% presented obstructive pattern, 16.7% normal values and a significant increase of TLC (p=0.038) and RV (p=0.018) were observed. The RV raise was associated with mild peripheral eosinophilia or persistent eosinophilia (p=0.045). Mild peripheral eosinophilia at diagnosis was associated to its persistency after treatment (p=0.023). CONCLUSION: In this series, mild peripheral eosinophilia was associated with its persistency and respiratory hyperinflation after treatment, suggesting that the degree of peripheral eosinophilia is associated to a distinct clinical evolution.