TY - JOUR T1 - The role of regional distribution (RD) of body fat mass (BFM) in fat-bone interactions in men with chronic obstructive pulmonary disease (COPD) JF - European Respiratory Journal JO - Eur Respir J VL - 40 IS - Suppl 56 SP - P2233 AU - Sviatlana Lemiasheuskaya AU - Alexander Makarevich AU - Alla Shepelkevich AU - Natalia Vasileva Y1 - 2012/09/01 UR - http://erj.ersjournals.com/content/40/Suppl_56/P2233.abstract N2 - The aim: Evaluation of the relationships between RD of BFM and TNF-α, some hormones and markers of bone metabolism.Methods: We used DEXA to analyze RD of BFM. We determined: serum leptin (L), testosterone free (TF), TNF-α, parathyroid hormone (PTH), beta-crosslaps (beta-CTX) and osteocalcin. We examined 83 COPD pts (40-70 yrs old) and control group – 15 healthy comparable men. The COPD pts were subdivided into 3 groups (GOLD).Results: Fat mass (FM) in Android region (A) positively correlated with TNF-α (r=0.33, p=0.02) in all pts group. Trunk and Arms FM were positively related to L (r=0.36 and r=0.35; respectively) in all pts group. L level exerted negative influence on bone mineral density (BMD) in lumbar spine (r=-0.43, p=0.001), but not at femoral necks in total group. We found the positive correlations between beta-CTX and total FM (r=0.33) and FM in A (r=0.32) in all pts group. The total, arms, legs and trunk FM, FM in Android and Gynoid (G) regions were increased in pts with a lower level of TF (p<0.05). Loss of BMD positively correlated (p<0.05) to loss of BMI, A/G ratio, FM in all body regions, PTH, calcium ionized and was inversely related with L level in all pts group. Although these pts had decrease of BMD, BMI was increased (29.4 in pts with osteopenia and 24.7 kg/m2 – with osteoporosis). Lowering of BMD might result from other factors, such as TNF-α and some hormones which are produced by the adipose tissue.Conclusion: The study of RD of adipose tissue in the patient's body is more informative than BMI for assessing the likelihood of developing osteoporosis in men with COPD. ER -