RT Journal Article
SR Electronic
T1 Time trends in multidrug-resistant tuberculosis
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP 200
VO 40
IS Suppl 56
A1 Matteo Zignol
A1 Dennis Falzon
YR 2012
UL http://erj.ersjournals.com/content/40/Suppl_56/200.abstract
AB Background: To investigate time trends in multidrug-resistant tuberculosis (MDR-TB) in different geographical settings worldwide we used data collected by the World Health Organization over the period 1994-2010.Methods: Time trends in MDR-TB rates from 45 countries or territories were calculated by multiplying the new TB case notification rates by the frequency of MDR-TB in new TB cases in the same year. The number of available country-year data points differed between countries. The annual percentage change in MDR-TB rates was plotted against the annual percentage change in TB notification rates, placing all countries or territories in one of six groupings according to whether MDR-TB rates and TB notification rates were increasing or decreasing.Results: In countries like Japan, Poland, Singapore and the US, the incidence of MDR-TB has been falling quicker than the incidence of TB. Countries with a high proportion of MDR-TB among TB cases (Georgia, Russian Federation: Tomsk Oblast), with a majority of TB cases of foreign origin (Sweden, United Kingdom) and with high HIV prevalence (Botswana, South Africa: Mpumalanga Province, Swaziland) show net increments in both TB and MDR-TB incidence, with the latter increasing faster than the former.Conclusions: While global trends in MDR-TB may not be inferred directly from the national data currently available, MDR-TB incidence is increasing in countries with disparate epidemiological and geographical settings.