PT  - JOURNAL ARTICLE
AU  - Chun-rong Ju
AU  - Rong-chang Chen
TI  - Serum surfactant protein D: Biomarker of chronic obstructive pulmonary disease
DP  - 2012 Sep 01
TA  - European Respiratory Journal
PG  - P3468
VI  - 40
IP  - Suppl 56
4099  - http://erj.ersjournals.com/content/40/Suppl_56/P3468.short
4100  - http://erj.ersjournals.com/content/40/Suppl_56/P3468.full
SO  - Eur Respir J2012 Sep 01; 40
AB  - Background: Surfactant protein D (SP-D) is a lung-specific protein proposed to predict clinical outcomes in patients with chronic obstructive pulmonary disease (COPD). However, the changes in serum SP-D during acute exacerbation (AECOPD) episodes and the relationship of serum SP-D with the overall severity of the disease in stable COPD (SCOPD) remain unclear.Methods: Serum SP-D levels were analyzed in three groups, including AECOPD (n = 40), SCOPD (n = 71), and controls (n = 60). In AECOPD group, serum SP-D levels were determined at 1, 5, 14, and 30 days post-exacerbation. In SCOPD group, BODE (body mass index, airflow obstruction, dyspnea, exercise capacity) index was evaluated for severity assessment.Results: Serum SP-D levels were sequentially elevated from the controls to the SCOPD, and then to the AECOPD (p < 0.001). During an AECOPD episode, the raised serum SP-D levels subsided at day 5 (p > 0.05), fell markedly at day 14 (p < 0.001), and continued to decline at day 30 (p < 0.001). Among patients with SCOPD, serum SP-D levels correlated positively with the BODE index (p < 0.01).Conclusions: The longitudinal changes in serum SP-D levels during an AECOPD episode suggest that SP-D may be a potential systemic biomarker for COPD exacerbation. The correlation of serum SP-D levels with the BODE index suggests that circulating SP-Ds can reflect the overall severity of SCOPD.