PT - JOURNAL ARTICLE AU - Anna Rita Mazzotta AU - Maria Elena Liverani AU - Alessandra Macari AU - Giuliano Tocci AU - Filomena Ianniello AU - Maria Pia TI - The effects of obstructive sleep apnea syndrome on cognitive and cardiovascular functioning in children with obesity DP - 2012 Sep 01 TA - European Respiratory Journal PG - P1077 VI - 40 IP - Suppl 56 4099 - http://erj.ersjournals.com/content/40/Suppl_56/P1077.short 4100 - http://erj.ersjournals.com/content/40/Suppl_56/P1077.full SO - Eur Respir J2012 Sep 01; 40 AB - Background: Paediatric obesity and sleep disordered breathing may be associated with cognitive problems and cardiovascular abnormalities and both may share the same common inflammatory and metabolic pathogenesis.Aim: to evaluate and compare cardiovascular activity and cognitive functions of obese children with or without clinical obstructive sleep apnea syndrome (apnea hypopnea index >5 n/h of sleep).Methods: obese children underwent polysomnography in a standard laboratory setting, a neurocognitive assessment and a 24-hour ambulatory blood pressure monitoring.Results: We studied ten children (mean age 9.2±3.2 years, 6 males), with a mean body mass index (BMI) of 27.67 kg/m2, a mean BMI percentile of 124.2±20.7. They had a mean apnea-hypopnea index of 9.6±13.6 n/h, an overnight oxygen saturation of 96.9±0.9 %. Mean values of blood pressure did not show relevant differences between diurnal and nocturnal measurements: diurnal systolic and diastolic pressure were 114.8±22.2 and 68.5±10.3 mmHg, while nocturnal systolic and diastolic pressure were 110.7 ±10.9 and 66.1 ±14.3 mmHg. Wechsler Intelligence Scale for Children-revised revealed a mean total intelligent quotient score of 91.3±15.21, a mean verbal intelligent quotient (VIQ) score of 95.7±12.4, and a mean performance intelligence quotient scores of 90.3±20. Compared to those without clinical sleep apnea, children with AHI>5 n/h had a lower VIQ (89.3±9.3 vs 102.0±13.4).Conclusions: Preliminary data showed that obese children had a peculiar blood pressure profile since they did not show the physiologic nocturnal deep. Obese children with obstructive sleep apnea display a specific verbal cognitive dysfunctions.