PT - JOURNAL ARTICLE AU - Ileana Stoicescu AU - Diana Ionita AU - Daniela Dospinoiu AU - Camelia Nita AU - Felicia Cojocaru AU - Alina Croitoru AU - Madalina Burecu AU - Carmen Stroescu AU - Irina Strambu TI - Exhaled nitric oxide correlations in patients with controlled and partially controlled asthma DP - 2012 Sep 01 TA - European Respiratory Journal PG - P3428 VI - 40 IP - Suppl 56 4099 - http://erj.ersjournals.com/content/40/Suppl_56/P3428.short 4100 - http://erj.ersjournals.com/content/40/Suppl_56/P3428.full SO - Eur Respir J2012 Sep 01; 40 AB - Aim: To assess NIOX values correlations with other disease characteristics in patients with controlled and partially controlled asthma.Subjects and methods: Patients with controlled and partially controlled asthma performed exhaled nitric oxide (NIOX), spirometry, bronchodilator test and blood eosinophils measurements. The allergic rhinitis history was noted. Correlations between NIOX values and the other parameters were calculated.Results: 42 asthma patients were evaluated: mean age 43, 14 males; 24 had controlled and 18 partially controlled asthma.NIOX values varied between 5 and 151 ppb (mean 41) in the whole group of 42 patients.All the tested parameters differ between the two groups. Significant differences were only seen in baseline FEV1 value (75% from predicted in the partially controlled, 85% in the controlled, p= 0.035) and blood eosinophils values (371/mmc, 4.5% in the partially controlled, p=0.012; 155/mmc and 2.3% in the controlled asthma patients, p=0.023).In the whole group of 42 patients NIOX values correlated with blood eosinophils (r=0.492, p=0.001), not with FEV1 values or the dFEV1 increase after the bronchodilator administration (p>0.05).The correlations were similar when the two groups were analyzed separately. NIOX values correlations with blood eosinophils values were r=0.577, p=0.012 in the partially controlled, and r=0.412, p=0.046 in the controlled group.No correlations were seen related to the presence of allergic rhinitis.Conclusions: Exhaled nitric oxide values showed high variability and only correlated with blood eosinophils values in our group of patients, regardless of asthma control.