PT  - JOURNAL ARTICLE
AU  - Eugenia Elfimova
AU  - Alexander Litvin
AU  - Kirill Zykov
TI  - The lymphocyte subset analysis in patients with arterial hypertension and severe obstructive sleep apnea syndrome
DP  - 2012 Sep 01
TA  - European Respiratory Journal
PG  - P3192
VI  - 40
IP  - Suppl 56
4099  - http://erj.ersjournals.com/content/40/Suppl_56/P3192.short
4100  - http://erj.ersjournals.com/content/40/Suppl_56/P3192.full
SO  - Eur Respir J2012 Sep 01; 40
AB  - Preliminary data of the study investigating peculiarities of inflammatory response and endothelial function in pts with arterial hypertension (AH) and obstructive sleep apnea syndrome (OSAS).The aim: The aim was to evaluate the count of lymphocyte subset in pts with AH and OSAS.Design and Methods: In 7 male pts with AH (office BP 151 ±5,2/ 91,4 ± 8,4 mmHg) and severe OSAS (AHI 64,8 ±15) and otherwise healthy, aged 39±11 years phenotyping of lymphocytes was performed by flow cytometry (Cytomics FC500, Beckman Coulter, USA).Results: pts with AH and severe OSAS were examined for levels for following parameters see the table.View this table:Parameters of cellular immunity in patients with AH and severe OSAThe levels of D3-HLA-DR+ and CD3+CD(16+56) and CD 50+ were statistically higher vs average normal values, whilst CD3+HLA-DR+, CD3+CD95+ were significantly lower.Conclusion: These data suggest, that both CD4+ and CD8+ T-cell compartments, as well as the regulation of CD95+ expression on T-cells, should be targeted for further study. Knowing of the underlying inflammatory mechanism could lead to understanding of disease progression and development of cardiovascular complications.