TY - JOUR T1 - Association between particulate air pollution and hospital admissions, mortality and acute exacerbations for chronic obstructive pulmonary disease in Beijing, China JF - European Respiratory Journal JO - Eur Respir J VL - 40 IS - Suppl 56 SP - 4523 AU - Ya Chen AU - Rui Zhu AU - Fu Deng AU - Wan Yao Y1 - 2012/09/01 UR - http://erj.ersjournals.com/content/40/Suppl_56/4523.abstract N2 - Background: Numerous studies with varying associations between particulate air pollution and chronic obstructive pulmonary disease (COPD) have been reported.Objective: To determine the association between air pollutants and hospital admissions, mortality and acute exacerbations for COPD in Beijing and identify which pollutants contributed most to this effect.Methods: Data of patients with COPD and air pollutants in Beijing were obtained from Peking University Third Hospital and Haidian District Environment Protection Bureau. We analyzed monthly hospital admissions, mortality and acute exacerbations for COPD and air pollutants data using Poisson regression in generalized additive models, adjust for the mean temperature, pressure and relative humidity.Results: In the single-pollutant model, an interquartile range (IQR) change of PM10 was associated with a 29.7% (7.9% to 55.9%) increase in hospital admissions for COPD. An IQR change of SO2 and NO2 were associated with a 64.5% (14.1% to 137.1%) increase and a 35.3% (-54.3% to -8.2%) decrease in COPD mortality respectively. While in the multiple-pollutant model, an IQR change of PM10 and NO2 were associated with a 46.4% (11.4% to 92.3%) increase and a 52.9% (-68.7% to -29.1%) decrease in COPD mortality. And SO2 and NO2 were associated with a 125.0% (61.3% to 214.0%) increase and a 61.5% (-66.0% to -32.8%) decrease in COPD mortality.Conclusion: Ambient concentrations of pollutants have an adverse effect on hospital admissions and mortality for COPD in Beijing.Grant: National Natural Science Foundation of China (No.81170012). ER -