RT Journal Article
SR Electronic
T1 Two single nucleotide polymorphisms in TSLP gene promoter region are associated with asthma susceptibility in Chinese Han population
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP P470
VO 40
IS Suppl 56
A1 Wen Liu
A1 Liang Dong
YR 2012
UL http://erj.ersjournals.com/content/40/Suppl_56/P470.abstract
AB Background: Asthma is a chronic inflammatory disease of the airway. Thymic stromal lymphopoietin(TSLP) can aggravate asthmatic lung inflammation. Objective: To analyze the polymorphism of two single nucleotide polymorphisms(SNPs) Rs2289276 and Rs2289278 in TSLP gene promoter region and to evaluate the association between the two SNPs and asthma susceptibility in Chinese Han population. Methods: 531 asthmatic patients and 540 normal controls were collected and the genotypes of SNPs Rs2289276 and Rs2289278 were detected with polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP), genotype and allele frequency were calculated and analyzed with Chi-square test. Results: The genotype and allele frequencies of the two SNPs in asthma patients were significantly different from those in the healthy controls.View this table:Table 1Rs2289278 C allele was correlated with decreased FEV1: FVC (P≤0.05).Conclusions: TSLP variants are significantly associated with bronchial asthma. TSLP might be a new therapeutic target molecule for asthma.