PT  - JOURNAL ARTICLE
AU  - Kamal Ali
AU  - Ravindra Bhat
AU  - Kim Wolff
AU  - Simon Hannam
AU  - Gerrard Rafferty
AU  - Anne Greenough
TI  - Ventilatory response to hypercarbia in newborns of smoking and substance abusing mothers
DP  - 2012 Sep 01
TA  - European Respiratory Journal
PG  - 3293
VI  - 40
IP  - Suppl 56
4099  - http://erj.ersjournals.com/content/40/Suppl_56/3293.short
4100  - http://erj.ersjournals.com/content/40/Suppl_56/3293.full
SO  - Eur Respir J2012 Sep 01; 40
AB  - Infants of smoking and substance abusing mothers have an increased risk of sudden infant death. A possible explanation for the association is that such infants have neurodevelopmental abnormalities which adversely affect the control of ventilation.Aims: To test the hypothesis that infants of substance abusing mothers (SA) and of smoking mothers (SM) compared to infants of non substance abusing, non-smoking mothers (controls) would have a poorer ventilatory response to hypercarbia.Methods: Infants were assessed before maternity/neonatal unit discharge. Respiratory flow (and tidal volume) was measured using a pneumotachograph inserted into a face mask placed over the infant's mouth and nose. The ventilatory responses to three levels of inspired carbon dioxide (baseline = 0%, 2% and 4% CO2) were assessed.Results: 8 SA, 15 SM and 15 control infants were assessed. The birth weight of the controls was higher than the SA and SM infants (p=0.01). At baseline SA infants had a higher respiratory rate (p=0.03) and minute volume (p=0.049) compared to controls and SM infants (Table). Both the SA and SM infants had a lower respiratory response to 2% (p=0.02) and 4% (p=0.004) CO2View this table:Conclusion: These results are consistent with infants of smoking and substance abusing mothers having a dampened ventilatory response to hypercarbia.