RT Journal Article
SR Electronic
T1 Relationship between sleep apnea syndrome, plasma myeloperoxidase levels and cardiovascular risk
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP P3822
VO 40
IS Suppl 56
A1 Ligia Puiu
A1 Andreea Didilescu
A1 Anca Petrovan
A1 Felicia Gliga
A1 Ovidiu Fira-Mladinescu
A1 Elena Dantes
A1 Monica Marc
A1 Florin Mihaltan
YR 2012
UL http://erj.ersjournals.com/content/40/Suppl_56/P3822.abstract
AB Background: In Sleep Apnea Syndrome (SAS) the episodes of hypoxia/reoxygenation results in the generation of reactive oxygen or nitrogen species by alternative pathways that involve the catalytic activity of myeloperoxidase (MPO) and promote oxidative stress. Aims and objectives: To assess the relationship between obstructive sleep apnea and plasma MPO levels, in SAS patients, comparing to a control group. Methods: Two Romanian groups, consisting of 40 patients diagnosed with SAS and 26 healthy controls, were recruited. All subjects underwent cardiorespiratory poligraphy. Plasma levels of MPO, total cholesterol (TC), triglycerides, low density lipoprotein cholesterol (LDL-c), high density lipoprotein cholesterol (HDL-c), apolipoprotein B100 (apoB100), fibrinogen and uric acid were assessed. Statistical analysis was performed using Pearson correlations tests, two tailed t-test and one-way ANOVA test. Results: In the SAS group, correlations were found as follows: MPO-apoB100 (r=-0.37; p=0.04); MPO-TC (r=-0.37; p=0.04); MPO-fibrinogen (r=0.36; p=0.04); apnea/hypopnea index (AHI)-uric acid (r=0.36; p=0.02) while in the control group between oxygen desaturation index (ODI)-LDL-c (r=0.58; p=0.001); ODI-TC (r=0.59; p=0.001); AHI-triglycerides (r=0.47; p=0.01). With regard to the smoking status, hypopneas number and the TC/HDL-c ratio were statistically significant higher in smokers than in nonsmokers (p=0.01; respectively, p=0.02). Conclusions: Plasma MPO levels may be used as marker risk of inflammation and cardiovascular disease in SAS patients and possibly, as a candidate for clinical application.Key words: sleep apnea, oxidative stress, myeloperoxidase, blood lipids, atherosclerosis.