PT  - JOURNAL ARTICLE
AU  - Yuki Okada
AU  - Yuta Kono
AU  - Seiko Soeda
AU  - Hiroko Hara
AU  - Kosuke Araki
AU  - Masako To
AU  - Yasuo To
TI  - A useful physiological marker for evaluating the effect of indacaterol in COPD patients
DP  - 2013 Sep 01
TA  - European Respiratory Journal
PG  - P807
VI  - 42
IP  - Suppl 57
4099  - http://erj.ersjournals.com/content/42/Suppl_57/P807.short
4100  - http://erj.ersjournals.com/content/42/Suppl_57/P807.full
SO  - Eur Respir J2013 Sep 01; 42
AB  - [Introduction] Long-acting beta agonist (LABA) is a one of the choices of therapy for COPD. Indacaterol(IND), a new LABA is a LABA with high potency to agonise beta-2 adrenergic receptor so that it is recognized as a strong-partial agonist. It is also known that IND therapy improves lung function and patient’s QOL (Beeh KM et al COPD 2011). However, few data is available about the effect of IND on lung function details including RV and IC. Here we investigated the clinical details including pulmonary function tests before and after IND add-on therapy.[Methods] COPD patients (mean age 74±10yrs, F:M=0:7, stage I/II/III/IV= 3/3/1/0) were recruited from the outpatient department of The Fraternity Memorial Hospital, a leading teaching hospital in Tokyo. Lung function tests and questionnaire (COPD Assessment Test (CAT)) were carried out before and after 4 weeks of add-on therapy with IND.[Result]CAT score about dyspnoea during exercise was significantly improved after the therapy (2.8±1.5 before therapy, 1.8±1.7 after therapy, p<0.05). Regarding pulmonary function test, Vital capacity (VC) significantly increased after therapy (3.21±0.29L before therapy, 3.35±0.30L after therapy, p<0.05). IND therapy also increased IC, but it did not reach significant (2.07±0.30L before therapy, 2.27±0.30L after therapy, p=0.08). No significant improvement was detected in FEV1, Functional residual capacity (FRC), RV or total lung capacity (TLC).[Conclusion] IND clearly improved the symptoms during exercise. Furthermore, VC might be a most sensitive marker to indicate improvement of lung function after IND therapy.