RT Journal Article SR Electronic T1 Is volume assured ventilation always able to compensate volume loss in presence of leaks? JF European Respiratory Journal JO Eur Respir J FD European Respiratory Society SP 2855 VO 40 IS Suppl 56 A1 Annia Schreiber A1 Annalisa Carlucci A1 Piero Ceriana A1 Alessio Mattei A1 Cesare Gregoretti YR 2012 UL http://erj.ersjournals.com/content/40/Suppl_56/2855.abstract AB Background: Volume assured (VTG) ventilation is a pressure targeted mode aimed to guarantee a target tidal volume (Vt) by varying the inspiratory pressure between two preset pressure values. VTG ventilation has been used to correct sleep-related periodic hypoventilations during noninvasive ventilation (NIV). However, in this setting the likelihood of non-intentional leaks (NIL) may be high. Aim and Methods: In a bench study we wanted to assess the VTG NIL compensation algorithm in three turbine driven ventilators designed to set a VTG either with an EVC or with an ILC (Vivo50, Breas; PB560, Covidien; Ventimotion, Weimann). All ventilators were tested in random order using a lung simulator (Ingmar, ASL5000) in VTG Pressure Control mode with both the ILC and the EVC at three level of leaks (15, 27 and 37 l/min) and at three different conditions of respiratory mechanics: normal, obstructive and restrictive. Results: All the ventilators in the ILC configuration were able to maintain the VTG in all simulated conditions; conversely, during all simulated leak conditions when the EVC was used a significant fall both in Vt and inspiratory pressure compared to the baseline value was observed.Conclusions: All single circuit ventilators tested in ILC configuration were able to compensate the volume loss and to ensure the preset VTG in all leak conditions but failed to ensure the VTG when the EVC was used.