@article {GokdemirP1117, author = {Yasemin Gokdemir and Ela Erdem and Fazilet Karakoc and Bulent Karadag and Ihsan Nuri Akpinar and Refika Ersu}, title = {Factors predicting mortality in cystic fibrosis where lung transplantation can not be performed}, volume = {40}, number = {Suppl 56}, elocation-id = {P1117}, year = {2012}, publisher = {European Respiratory Society}, abstract = {Introduction: Cystic fibrosis is the most common lethal genetic disorder affecting the Caucasian population. Severe pulmonary disease is responsible for over 80\% of deaths associated with cystic fibrosis. Patients with less than 2 years life expectancy and with reduced quality of life are candidates for lung transplantation.Aim: To evaluate the risk factors of mortality in moderate to severe cystic fibrosis lung disease that doesn{\textquoteright}t go to lung transplantation.Material and methods: We follow up 200 cystic fibrosis patients in our clinic and 35 of them with FEV1 <=\%60 were enrolled to the study. Demographic data, pulmonary function test, high resolution computed tomography modified Bhalla score, blood gas analysis and nutritional status of patients were evaluated.Results: Respiratory support requirement was frequent in moderate to severe lung disease (31.4\%). Low pulmonary function, non invasive ventilation requirement, having diabetes mellitus, 02 saturation \<95, pCO2 \>50 mm Hg and frequent IV antibiotic treatment were significantly related with increased mortality (p\<0.05).Conclusion: This is a single centre study of cystic fibrosis patients with moderate to severe lung disease that did not go to lung transplantation. We evaluated the clinical going and factors that were associated with mortality. We think that it is important to do similar multicentre studies to discover Turkish CF patients{\textquoteright} information that have different genetics and phenotype.}, issn = {0903-1936}, URL = {https://erj.ersjournals.com/content/40/Suppl_56/P1117}, eprint = {https://erj.ersjournals.com/content/40/Suppl_56/P1117.full.pdf}, journal = {European Respiratory Journal} }