RT Journal Article SR Electronic T1 Pulmonary volumetric analyses based on three-dimensional computed tomography (3D-CT), compared with pulmonary function test JF European Respiratory Journal JO Eur Respir J FD European Respiratory Society SP P3209 VO 40 IS Suppl 56 A1 Hiroo Wada A1 Sayuki Hiraoka A1 Keiko Morita A1 Masamichi Koyanagi A1 Kenichi Yokoyama A1 Yoshinosuke Fukuchi A1 Toshiaki Nitatori A1 Hajime Goto YR 2012 UL http://erj.ersjournals.com/content/40/Suppl_56/P3209.abstract AB BACKGROUND Three-dimensional computed tomography (3D-CT) potentiates the application to the daily clinical practice.METHODS Forty four patients (30 COPD, 12 lung cancer, 2 miscellaneous) were enrolled in this study. Lung volumes (LV), as well as the low attenuation volume (LAV), were measured based on 3D-CT both at the end inspiratory volume (EIV) and at the end expiratory volume (EEV) and compared with the physiological data of ordinary pulmonary function tests.RESULTS & DISCUSSION Lung volumes determined using reconstituted 3D-CT images at end inspiratory volume (LVins), those at end expiratory volume (LVexp), and their difference (LVins – LVexp), were significantly associated with TLC (p<0.0001), RV (p<0.0001), VC (p=0.0028), respectively. Furthermore, the percentage of the LAV to LV at EIV (LAV%ins) was associated with the changes in the various results of pulmonary function tests, including FEV1, %FEV1, RV/TLC, VC. Both FEV1 and %FEV1 were associated with LAVexp and LVexp, in participants whose LAV were larger than 10mL. These results suggested that 3D-CT, taken at both EIV and EEV, provides the data not only on lung volumes in the static state, but also dynamic infomation. Furthermore, there is a significant association between the FEV1 and the difference between the normal attenuation volumes (NAV) of the 3D-CT at EIV and those at EEV (p<.001). This suggested that not only LAV but also NAV contributed to the airflow limitation, represented by FEV1 reduction.CONCLUSION 3D-CT reveals not only the physiologic properties, but also provides some insights into the mechanism of respiration.