TY - JOUR T1 - Complete blood count alterations after 6 months of continuous positive airway pressure treatment in patients with severe obstructive sleep apnea JF - European Respiratory Journal JO - Eur Respir J VL - 42 IS - Suppl 57 SP - P4009 AU - Sinem Sökücü AU - Cengiz Özdemir AU - Levent Dalar AU - Levent Karasulu AU - Senay Aydin AU - Sedat Altin Y1 - 2013/09/01 UR - http://erj.ersjournals.com/content/42/Suppl_57/P4009.abstract N2 - Study Objectives: The cardiovascular complications caused by obstructive sleep apnea (OSA) have been shown to be decreased after continuous positive airway pressure (CPAP). Mean platelet volume (MPV), platelet distribution width (PDW), and red cell distribution width (RDW) are newly recognized tools for assessment of cardiovascular risk.Methods: From a selection of patients with symptoms of nocturnal snoring and/or excessive day time sleepiness, 25 males with an apnea-hypopnea index (AHI) > 30/hr and 22 age-matched normal male controls with AHI 5/hr were included and complete blood count parameters were evaluated.Results: Compared to controls, MPV values were significantly higher (p=0.025) in the OSA patients but no significant differences in PDW or RDW were found (p>0.05). Six months of CPAP therapy was found to significantly lower MPV values but to increase the PDW and RDW in patients with severe OSA (p=0.001; p=0.007; p=0.001).View this table:Effects of 6 months CPAP treatment on severe OSA patientsConclusion: Our data suggest that in OSA patients, complete blood count parameters, such as MPV, PDW and RDW, change significantly after CPAP therapy. ER -