RT Journal Article
SR Electronic
T1 Cardiac autonomic nervous system is normal in dairy farmer with mild/moderate COPD
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP P4246
VO 42
IS Suppl 57
A1 Bruno Degano
A1 Frédéric Claudé
A1 Matthieu Veil-Picard
A1 Valérie Paulus
A1 Malika Bouhaddi
A1 Alexia Marescaux
A1 Antonin Grisey
A1 Jean-Jacques Laplante
A1 Martial Botebol
A1 Jean-Pierre Wolf
A1 Jacques Regnard
A1 Jean-Charles Dalphin
YR 2013
UL http://erj.ersjournals.com/content/42/Suppl_57/P4246.abstract
AB Background: A dysregulation of the cardiac autonomic nervous system, studied by baroreflex sensitivity (BRS), has been shown in patients with COPD related to cigarette smoking. Several factors including hypoxemia, poor physical fitness and pulmonary hyperinflation have been suspected. Occupational COPD is frequent in dairy farmers, but patients' characteristics might be different compared with smoking-related COPD.Objective: To examine the presence and eventually the causes of cardiac autonomic nervous dysregulation in dairy farmers with COPD.Methods: BRS was compared between 2 groups of patients with mild/moderate COPD (related either to cigarette smoking or to dairy farming) and 2 groups of healthy matched controls. Peak workload served to evaluate physical fitness. Pulmonary hyperinflation was judged by the ratio of inspiratory capacity (IC) on total lung capacity (TLC). PaO2 was measured at rest.Results: The main results are given in a Table.View this table:Main characteristics of COPD patients and controlsThere was a positive correlation between PaO2 and BRS (r2=0.16; p<0.0001)Conclusions: Depressed baroreflex sensitivity, a characteristic of smoking-related COPD, was not found in dairy farmers with mild/moderate COPD. This difference could be due to a lower PaO2 in smoking-related COPD patients.