RT Journal Article
SR Electronic
T1 FeNO (fractional exhaled nitric oxide) measurements in pregnant asthmatic women. The long-term, intra-subject variability of FeNO in controlled asthma
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP P2212
VO 40
IS Suppl 56
A1 Anna Dor-Wojnarowska
A1 Marita Nittner-Marszalska
A1 Robert Pawlowicz
A1 Hanna Marszalska
A1 Anna Kazimerczak
A1 Bernard Panaszek
YR 2012
UL http://erj.ersjournals.com/content/40/Suppl_56/P2212.abstract
AB BACKGROUND: Fractional exhaled nitric oxide (FeNO) is considered a good noninvasive marker to assess airway inflammation in asthma and allergic rhinitis. It has been also proposed that adjusting anti-inflammatory drugs guided by the monitoring of exhaled NO could improve overall asthma control. However standards, the assessment of long-term repeatability of this parameter as well as the rate of change which can be considered significant have not been established yet.The aim of our study was to assess the long-term, intra-subject variability of FeNO in pregnant asthmatic women with controlled asthma.METHODS: Pregnant, non-smoking women with asthma were recruited between 8 and 24 weeks of gestation. Exhaled nitric oxide (FeNO), lung function, and the asthma control test (ACT) were performed at monthly visits up to delivery. The data of 50 subjects with well controlled asthma (20-25 ACT, normal spirometric parameters, no change in treatment) during pregnancy were analyzed. The variability of the FeNO parameter was assessed in asthmatics using the variation coefficient (standard deviation x 100% / average).RESULTS: FeNO showed high coefficient of variation (CV): 35.8% (Me 32;Min 2.45, Max 121,9) in all women with well controlled asthma during pregnancy. There was no significant difference in CV between atopic 36,2% (35,5; 2,45-121,9) and nonatopic 33,9% (25,5; 11-71,9) asthmatic women (p= 0,98).CONCLUSIONS: Long-term variation of FeNO was found to be not satisfactory because the variation coefficient was 35.8%. It means that changes of FeNO should be interpreted with caution.