RT Journal Article
SR Electronic
T1 Longitudinal relationship between physical activity and lung health in patients with cystic fibrosis
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP 817
OP 823
DO 10.1183/09031936.00055513
VO 43
IS 3
A1 Jane E. Schneiderman
A1 Donna L. Wilkes
A1 Eshetu G. Atenafu
A1 Thanh Nguyen
A1 Greg D. Wells
A1 Nancy Alarie
A1 Elizabeth Tullis
A1 Larry C. Lands
A1 Allan L. Coates
A1 Mary Corey
A1 Felix Ratjen
YR 2014
UL http://erj.ersjournals.com/content/43/3/817.abstract
AB Exercise is beneficial for patients with cystic fibrosis (CF) but long-term effects of physical activity on lung function evolution are unknown. We evaluated the longitudinal relationship between changes in habitual physical activity (HPA) and rate of decline in lung function in patients with CF. We tracked HPA using the Habitual Activity Estimation Scale, forced expiratory volume in 1 s (FEV1) and Stage I exercise tests in 212 patients with CF over a 9-year period. Adjusting for sex, baseline age and FEV1, mucoid Pseudomonas aeruginosa and CF-related diabetes, mean±sd FEV1 % predicted decreased by 1.63±0.08% per year (p<0.0001) while mean±sd HPA increased by 0.28±0.03 h·day−1 per year (p<0.0001) over the study period. A greater increase in HPA was associated with a slower rate of decline in FEV1 (r=0.19, p<0.0069). Dividing subjects into “high” and “low” activity (above or below the mean rate of change of activity, respectively), a steeper rate of FEV1 decline was observed for low (-1.90% per year) compared to high (-1.39% per year) (p=0.002). Increases in HPA are feasible despite progression of lung disease and are associated with a slower rate of decline in FEV1, highlighting the benefit of regular physical activity, and its positive impact on lung function in patients with CF. FEV1 declines at a lesser rate in patients with cystic fibrosis who increase their activity levels http://ow.ly/rETZc