@article {de RaafP3926, author = {Michiel Alexander de Raaf and Ingrid Schalij and Anton Vonk-Noordegraaf and Frances de Man and Harm Jan Bogaard}, title = {Telemetric right ventricular pressure measurements and serial echocardiography in experimental pulmonary arterial hypertension}, volume = {40}, number = {Suppl 56}, elocation-id = {P3926}, year = {2012}, publisher = {European Respiratory Society}, abstract = {This study characterized hemodynamic changes in the Sugen-Hypoxia (SuHx) model by telemetric acquisition and echocardiography. The SuHx rat model is based on the combined exposure to the VEGF-receptor inhibitor SU5416 and hypoxia and is used in Pulmonary Arterial Hypertension (PAH) research due its histological features resembling the plexogenic pulmonary vascular remodeling seen in human PAH.SU5416 (25 mg/kg s.c.) was administered and animals were housed at 10\% oxygen for 4 weeks, followed by re-exposure to normoxic conditions. Telemetric right ventricular pressure acquisition was continuous from surgery onwards. Serial echocardiography was performed weekly under anesthetic conditions. Spearman correlations were calculated between echocardiographic parameters and telemetric RVSP.Telemetric RVSP increased immediately after administration of SU5416 and exposure to hypoxia. In the consecutive re-exposure to normoxic conditions, a considerable interindividual variability was observed. Echocardiographic parameters as Tricuspid Annular Plane Systolic Excursion (TAPSE), Right Ventricular End Diastolic Diameter (RVEDD) and Pulmonary Artery Acceleration Time divided by cardiac cycle length (PAAT/cl) showed hypoxic adaptation, but post-hypoxic differences were less pronounced. RVEDD, but not PAAT/cl and TAPSE was significantly correlated to RVSP.Telemetry and echocardiography both show a progressive response in the hypoxic period. Individual variability among animals resulted in different RVSP-responses upon re-exposure to normoxic conditions. RVEDD correlated significantly with RVSP, whereas TAPSE and PAAT/cl seemed not suitable as surrogate markers for RVSP.}, issn = {0903-1936}, URL = {https://erj.ersjournals.com/content/40/Suppl_56/P3926}, eprint = {https://erj.ersjournals.com/content/40/Suppl_56/P3926.full.pdf}, journal = {European Respiratory Journal} }