@article {GuptaP2514, author = {Anupama Gupta and Rajesh Gupta and Sushma Sood and Ankur Agarwal}, title = {Correlation between muscular dysfunction and vascular inflammation in COPD}, volume = {42}, number = {Suppl 57}, elocation-id = {P2514}, year = {2013}, publisher = {European Respiratory Society}, abstract = {Background: Pulse wave velocity (PWV) a marker for vascular inflammation has been correlated with EMG for myopathy in COPD.Material \& methods: 50 known COPD patients for 5 years or more, age 40 years or more and 50 controls, healthy volunteers with matched age and sex included in study. Routine investigations to r/o other illness and specific tests i.e. PWV measured in three different segments using pulse transducers simultaneous ECG recorded on four channel polygraph and EMG of Quadriceps recorded using needle electrodes, inserted at the insertion point using sweep speed of 5-10 ms/div and amplification of 50{\textmu}v/division for studying spontaneous activity and 200{\textmu}V/divisions for Motor Unit Potentials to correlate with each other and various determinants of COPD.Results: The mean PWV values increased significantly in COPD group of segments AO-Rad, AO-Fem and Fem-Dp 6.244{\textpm}1.168, 6.86{\textpm}.990 \& 8.56{\textpm}1.110 than in controls 5.144{\textpm}.664, 5.40{\textpm}.782 and 7.10{\textpm}.678 respectively. The mean EMG value of amplitude of Rectus Femoris and Vastus Medialis in COPD patients was 1278.42{\textpm}840.81 and 799.90{\textpm}598.635 respectively, significantly decrease to 53.54\% and 66.03\% of control value.Discussions: PWV had significantly negatively correlated with the FEV1/FVC in the COPD group, more affected in AO-Fem segment increased to 27.05\% compared to controls. EMG values i.e. recruitment and amplitude significantly decreased in COPD patients compared to controls. Vastus Medialis was more severely affected while amplitude represented a correlation with FVC and duration of illness.Smoking pack years was important factors for myopathy in COPD though no correlation was seen between EMG and PWV.}, issn = {0903-1936}, URL = {https://erj.ersjournals.com/content/42/Suppl_57/P2514}, eprint = {https://erj.ersjournals.com/content/42/Suppl_57/P2514.full.pdf}, journal = {European Respiratory Journal} }