RT Journal Article SR Electronic T1 A comparison of the frequency of cough with laughter in asthmatic and non asthmatic patients JF European Respiratory Journal JO Eur Respir J FD European Respiratory Society SP 163 VO 40 IS Suppl 56 A1 Christopher Leahy A1 Bernard Leahy YR 2012 UL http://erj.ersjournals.com/content/40/Suppl_56/163.abstract AB Cough is a frequent symptom in asthmatic patients.Cough may be induced by typical asthma triggers such as allergens,exertion or change in atmospheric temperature.This study investigates the symptom of cough with laughter as an asthmatic symptom.Patients attending a general adult respiratory clinic were routinely asked if they experienced cough with laughter.Seventy four consecutive patients with a single respiratory diagnosis were included.The patients were divided into two groups-patients with asthma and those with another respiratory diagnosis.The asthma group had forty three patients with a mean age of 57.7 years,twenty seven were female and sixteen male.The non asthma group had thirty one patients with a mean age of 63.9 years,sixteen were male and fifteen female.In this second group their diagnoses were chronic obstructive pulmonary disease in eleven,pulmonary fibrosis in eight,sarcoidosis in five,bronchiectasis in two,hyperventilation in two and one each of carcinoma of bronchus,tuberculosis and sleep apnoea.In the asthma group forty two of the forty three patients had the symptom of cough with laughter.In the non asthma group one of the thirty one patients had the symptom of cough with laughter.The symptom of cough with laughter is highly significantly associated with a diagnosis of asthma compared to other respiratory diagnoses(p<0.0001) and has a 97.6% sensitivity and a 96.8% specificity as an asthma symptom in this study.