RT Journal Article SR Electronic T1 Idiopathic pulmonary fibrosis (IPF) and gastroeosophageal disorders JF European Respiratory Journal JO Eur Respir J FD European Respiratory Society SP P2331 VO 42 IS Suppl 57 A1 Josipa Kokeza A1 Kornelija Mise A1 Zeljko Puljiz A1 Anteo Bradaric A1 Emilija Lozo A1 Josko Mise YR 2013 UL http://erj.ersjournals.com/content/42/Suppl_57/P2331.abstract AB Introduction: IPF is a disease of unknown etiology, frequent in person older than 65 years. It relates with gastroesophageal (GE) reflux disease.Goal: to examine GE system of people with newfound IPF before including the therapy (corticosteroids, bronchodilators) for lungs' problems which could seriously harm the GE system. And to determine the pH value in the lungs.Methods: at any newfound IPF (by the principles of ATS/ ERS) gastroscopy and determination of the pH value in the respiratory system during the bronchoscopy were done.Results: 32 patients were examined, 22 men, 10 women, X = 64.66±11.12 year.Results of pulmonary function tests showed: FVC%: 86.64± 22.62, FEV1%:90.85± 18.34, DLco%:59.56± 14.33, Kco%:58.92± 20.07, pO2 kPa: 9.46± 1.98, pCO2 kPa: 4.42±0.87.Gastroscopy showed these findings: GE reflux (1- 3 stage) in 30 pts (93.75%), hiatal hernia in 21 pts, hypersecretion in 22 pts, Helicobacter pylori infection in 25 and ulcer in 11 pts. Combination of these findings were present in 84.3% of the pts. Acidity in the bronchi was X= 5.26±0.46 (5.0-6.5). Value of pH in the lungs with bacterial infections: X = 7.88±0.33.Conclusion: changes in the GE system were found in almost every patient, 75% (24/32) had symptoms, others had "silent" GE reflux. High percentage of H. pylori was found (78%). The values of pH in the bronchi/ lungs were extremely low (5-6.5). H. pylori was not found in the biopsy specimen of the lungs. The question is could long lasting GE reflux cause IPF?