TY - JOUR T1 - Cell composition of induced sputum in patients with uncontrolled asthma and its participation in the formation of cold airway hyperresponsiveness JF - European Respiratory Journal JO - Eur Respir J VL - 42 IS - Suppl 57 SP - P2022 AU - Tatiana A. Maltseva AU - Aleksey B. Pirogov AU - Victor P. Kolosov AU - Elena V. Ushakova AU - Svetlana V. Naryshkina Y1 - 2013/09/01 UR - http://erj.ersjournals.com/content/42/Suppl_57/P2022.abstract N2 - Background: Little is known about the role of airway inflammation pattern in the formation of cold airway hyperresponsiveness (CAHR).Aim: to define the role of the pattern of airway inflammation in the patients with bronchial asthma (BA) in the development of CAHR.Methods: 38 patients with uncontrolled BA were examined. The cell composition in induced sputum was identified a day before the bronchoprovocation by 3-minute isocapnic hyperventilation with cold (-20º) air (IHCA).Results: Two patterns of bronchial inflammation were identified in the patients. The first is the eosinophil pattern with the predominant number of regulators of allergic reaction which is typical for the allergic BA. The 1st group (14 patients) had the biggest quantity of eosinophils (15.56±1.27%), the less quantity of macrophages (53.1±3.4%) and neutrophils (24.9±3.1%). The second is the neutrophil-macrophage pattern which is typical for the mixed BA. The 2nd group (24 patients) had increase of macrophages (65.3±4.1%), neutrophils (34.4±2.7%) and the decrease of eosinophils (11.46±1.37%) in comparison with the 1st group (p<0.05). The initial level of the asthma control was significantly higher in the 1st group in comparison with the 2nd one: 17.9±0.3 and 14.9±0.2 points ACT, respectively (p<0.001). 79% patients had CAHR in the 2nd group and 29% in the 1st group (p<0.01). The FEV1 drop in response to ICAH was higher in the 2nd group: -18.6±1.39 and -13.1±1.24%, respectively (p<0.01).Conclusion: The neutrophil-macrophage pattern of bronchial inflammation dominates at the formation of CAHR and the low level of the asthma control. ER -