PT  - JOURNAL ARTICLE
AU  - Jane Kirkby
AU  - Janet Stocks
AU  - Sooky Lum
AU  - Padmanabha Rao
AU  - Samatha Sonnappa
TI  - Global lung function initiative (GLI) spirometry equations: Comparison of lung function between indigenous Indian and UK-Indian children
DP  - 2013 Sep 01
TA  - European Respiratory Journal
PG  - P1224
VI  - 42
IP  - Suppl 57
4099  - http://erj.ersjournals.com/content/42/Suppl_57/P1224.short
4100  - http://erj.ersjournals.com/content/42/Suppl_57/P1224.full
SO  - Eur Respir J2013 Sep 01; 42
AB  - Background: The GLI recently produced all-age, multi-ethnic reference equations for spirometry (Quanjer, ERJ 2012), but equations for the Indian-subcontinent are not yet available.Aim: To compare spirometry results from healthy urban indigenous Indian and UK-Indian children and ascertain whether any of the ethnic-specific GLI equations are appropriate for these children.Methods: Identical spirometry protocols and equipment (EasyOn-PC, NDD) were used in 5-12y old children in London and Bangalore. Results were interpreted using each GLI ethnic-specific equation to ascertain best fit.Results: Acceptable results were achieved in 348 indigenous Indian and 289 UK-Indian children (mean(SD)age:8.7(1.8)y. There was no significant difference in height z-score or in any spirometric outcome (figure1). In comparison with GLI-White reference data, FEV1 and FVC were 10% lower in all Indian children, but FEV1/FVC was similar. SE Asian equations were most appropriate for FEV1 and FVC (mean(SD)z-score:-0.1(0.9)z and 0.2(0.9)z respectively), but under-estimated FEV1/FVC (-0.7(0.8)z).Conclusion: GLI-SE Asian equations are applicable for FEV1 and FVC in urban Indian children whether living in India or the UK, however FEV1/FVC should be based on GLI-White. Further work to develop specific coefficients for the Indian subcontinent across all ages is required.Funding: Wellcome Trust, Asthma UK.