RT Journal Article
SR Electronic
T1 Acute exacerbation of idiopathic pulmonary fibrosis associated with air pollution exposure
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP 1124
OP 1131
DO 10.1183/09031936.00122213
VO 43
IS 4
A1 Kerri A. Johannson
A1 Eric Vittinghoff
A1 Kiyoung Lee
A1 John R. Balmes
A1 Wonjun Ji
A1 Gilaad G. Kaplan
A1 Dong Soon Kim
A1 Harold R. Collard
YR 2014
UL http://erj.ersjournals.com/content/43/4/1124.abstract
AB Acute exacerbations of idiopathic pulmonary fibrosis are associated with high mortality and are of unknown cause. The effect of air pollution on exacerbations of interstitial lung disease is unknown. This study aims to define the association of air pollution exposure with acute exacerbation of idiopathic pulmonary fibrosis. Patients with idiopathic pulmonary fibrosis and corresponding air pollution data were identified from a longitudinal cohort. Air pollution exposures were assigned to each patient for ozone, nitrogen dioxide, particulate matter, sulfur dioxide and carbon monoxide based on geo-coded residential addresses. Cox proportional hazards models were used to estimate the association of air pollution exposures and acute exacerbations. Acute exacerbation was significantly associated with antecedent 6-week increases in mean level, maximum level and number of exceedances above accepted standards of ozone (hazard ratio (HR) 1.57, 95% CI 1.09–2.24; HR 1.42, 95% CI 1.11–1.82; and HR 1.51, 95% CI 1.17–1.94, respectively) and nitrogen dioxide (HR 1.41, 95% CI 1.04–1.91; HR 1.27, 95% CI 1.01–1.59; and HR 1.20, 95% CI 1.10–1.31, respectively). Increased ozone and nitrogen dioxide exposure over the preceding 6 weeks was associated with an increased risk of acute exacerbation of idiopathic pulmonary fibrosis, suggesting that air pollution may contribute to the development of this clinically meaningful event. Acute exacerbation of idiopathic pulmonary fibrosis is associated with increased ozone and nitrogen dioxide exposure http://ow.ly/t1vzw