RT Journal Article
SR Electronic
T1 Effects of apolipoprotein E genotype on serum lipids in obstructive sleep apnoea
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP 1097
OP 1105
DO 10.1183/09031936.00098513
VO 43
IS 4
A1 Radovan Tisko
A1 Zuzana Sopkova
A1 Viera Habalova
A1 Zuzana Dorkova
A1 Eva Slaba
A1 Martin Javorsky
A1 Ivan Tkac
A1 Renata L. Riha
A1 Ruzena Tkacova
YR 2014
UL http://erj.ersjournals.com/content/43/4/1097.abstract
AB There is increasing evidence that intermittent hypoxia resulting from obstructive sleep apnoea (OSA) is independently associated with dyslipidaemia. Currently, no data exist on potential links between OSA-related dyslipidaemia and susceptibility genes for dyslipidaemia in such patients. Our aim was to study the effects of the apolipoprotein E (APOE) genotype and sleep apnoea severity on atherogenic dyslipidaemia in patients with OSA. 519 clinically stable subjects prospectively recruited at a tertiary referral teaching hospital underwent full polysomnography. APOE gene polymorphisms were assessed using real-time PCR. In all APOE genotype groups, serum triglycerides increased while high-density lipoprotein (HDL) cholesterol was reduced with increasing severity of OSA in each APOE genotype group, whereas the deleterious effects of OSA on serum apolipoprotein (Apo)B levels were observed in ϵ2 carriers and the ϵ3/ϵ3 genotype only. Nevertheless, the ϵ4 allele carriers had ApoB levels within the risk range, irrespective of nocturnal hypoxia. In addition, among patients with the high-risk ϵ4 genotype, those with the most severe nocturnal hypoxia had significantly higher triglyceride and lower HDL cholesterol levels compared with nonhypoxic ϵ4 subjects. APOE genotype and the oxygen desaturation index were both independent predictors of serum triglyceride levels (p=0.009 and p<0.001, respectively; R2=0.148) and ApoB levels (p=0.001 and p=0.003, respectively; R2=0.104). Our findings suggest that OSA has adverse effects on several lipid parameters over and above the effects carried by APOE genotype. Further st1udies are needed to analyse the effects of high-risk genotypes on metabolic and cardiovascular outcomes in patients with OSA. OSA has adverse effects on several lipid parameters in addition to the effects carried by the APOE genotype http://ow.ly/sKOUW