RT Journal Article
SR Electronic
T1 Comparison of health status in stable patients with bronchiectasis due to common variable immune deficiency (CVID), and idiopathic bronchiectasis
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP p945
VO 38
IS Suppl 55
A1 Lorraine Ozerovitch
A1 Samantha Prigmore
A1 Winston Banya
A1 Robert Wilson
A1 Noel Snell
A1 Peter Kelleher
A1 Jillian Riley
YR 2011
UL http://erj.ersjournals.com/content/38/Suppl_55/p945.abstract
AB Background: Patients with CVID develop bronchiectasis (bx) due to damage caused by lung infections. Bx is associated with impaired health status (Wilson C et al Am J Respir Crit Care Med 1997; 156: 536-541). Improved treatment for CVID+bx has led to fewer infections but little is known about impact on health status.Methods: Patients undertook a Shuttle Walking Test (SWT) and completed the St George's Respiratory Questionnaire (SGRQ). Scores were compared with data from a previous study of idiopathic bx (Ozerovitch L et al Am J Respir Crit Care Med 2004; 169: A330).Results: 22 patients participated; 9 male (41%); mean age 45 (range 17-67); 20 (91%) on immunoglobulin (Ig) therapy. Patients with CVID+bx had better scores for all SGRQ domains, and better SWT, both of which were clinically relevant; SGRQ >4 point difference (Jones P, Eur Respir J 2002; 19: 398-404); SWT 60-115m (Pepin V et al, Thorax 2011;66:115-120), although neither attained statistical significance.View this table:There were no significant correlations between SWT and activity component or SGRQ Total Score (r= -0.45, p>0.05; r= -0.43, p>0.05) in the CVID with bx group.Conclusion: Patients with bx due to CVID have impaired health status and SWT; scores were generally better than for demographically similar historical controls with idiopathic bx, possibly as a result of specific therapy (Ig replacement) in the majority of these patients.