@article {Ozerovitchp945, author = {Lorraine Ozerovitch and Samantha Prigmore and Winston Banya and Robert Wilson and Noel Snell and Peter Kelleher and Jillian Riley}, title = {Comparison of health status in stable patients with bronchiectasis due to common variable immune deficiency (CVID), and idiopathic bronchiectasis}, volume = {38}, number = {Suppl 55}, elocation-id = {p945}, year = {2011}, publisher = {European Respiratory Society}, abstract = {Background: Patients with CVID develop bronchiectasis (bx) due to damage caused by lung infections. Bx is associated with impaired health status (Wilson C et al Am J Respir Crit Care Med 1997; 156: 536-541). Improved treatment for CVID+bx has led to fewer infections but little is known about impact on health status.Methods: Patients undertook a Shuttle Walking Test (SWT) and completed the St George{\textquoteright}s Respiratory Questionnaire (SGRQ). Scores were compared with data from a previous study of idiopathic bx (Ozerovitch L et al Am J Respir Crit Care Med 2004; 169: A330).Results: 22 patients participated; 9 male (41\%); mean age 45 (range 17-67); 20 (91\%) on immunoglobulin (Ig) therapy. Patients with CVID+bx had better scores for all SGRQ domains, and better SWT, both of which were clinically relevant; SGRQ \>4 point difference (Jones P, Eur Respir J 2002; 19: 398-404); SWT 60-115m (Pepin V et al, Thorax 2011;66:115-120), although neither attained statistical significance.View this table:There were no significant correlations between SWT and activity component or SGRQ Total Score (r= -0.45, p\>0.05; r= -0.43, p\>0.05) in the CVID with bx group.Conclusion: Patients with bx due to CVID have impaired health status and SWT; scores were generally better than for demographically similar historical controls with idiopathic bx, possibly as a result of specific therapy (Ig replacement) in the majority of these patients.}, issn = {0903-1936}, URL = {https://erj.ersjournals.com/content/38/Suppl_55/p945}, eprint = {https://erj.ersjournals.com/content}, journal = {European Respiratory Journal} }