PT  - JOURNAL ARTICLE
AU  - Ferenc Petak
AU  - Gergely Albu
AU  - Eniko Lele
AU  - Maurice Beghetti
AU  - Walid Habre
TI  - Prevention of adverse pulmonary consequences of myocardial ischaemia in rats
DP  - 2011 Sep 01
TA  - European Respiratory Journal
PG  - p855
VI  - 38
IP  - Suppl 55
4099  - http://erj.ersjournals.com/content/38/Suppl_55/p855.short
4100  - http://erj.ersjournals.com/content/38/Suppl_55/p855.full
SO  - Eur Respir J2011 Sep 01; 38
AB  - The efficiency of treatment strategies against airway hyperresponsiveness (AH) were compared following chronic postcapillary pulmonary hypertension induced by myocardial ischaemia (MI). Airway resistance (Raw) was measured in four groups of rats under baseline conditions, and following iv infusions of 2-18 μg/kg/min methacholine (MCh). Sham surgery was then performed in Group C, while the left interventricular coronary artery was ligated in the other groups without treatment (Group I), or daily treatments with combined angiotensin enzyme converter (ACE) inhibitor and diuretics (enalapril, lasix, Group IE), or a calcium channel blocker (diltiazem, Group ID). Eight weeks later, MCh provocations were repeated. Equivalent dose of MCh causing 50% increase in Raw (ED50) was determined. Left atrial pressure (Pla) was estimated from the end-diastolic left ventricular pressure. Elevations in Pla to MI (6.8±1.1 [SD] vs. 15.2±1.3 mmHg in Groups C and I, respectively) were not affected by the treatment in Group ID (13.7±3.1 mmHg), whereas they were inhibited in Group IE (10.9±3.2 mmHg, p=0.005). The development of AH following MI was completely abolished in both Groups ID and IE.These findings suggest the efficiency of combined ACE inhibitor and diuretics to protect the adverse pulmonary haemodynamical consequences of MI, while both treatment strategies have similar affinities to prevent AH.Supported by grants SNSF 3200B0-118231 and OTKA K81179.