TY - JOUR T1 - Beyond the IFN-γ horizon: biomarkers for immunodiagnosis of infection with <em>Mycobacterium tuberculosis</em> JF - European Respiratory Journal JO - Eur Respir J SP - 1472 LP - 1486 DO - 10.1183/09031936.00151413 VL - 43 IS - 5 AU - Novel N. Chegou AU - Jan Heyckendorf AU - Gerhard Walzl AU - Christoph Lange AU - Morten Ruhwald Y1 - 2014/05/01 UR - http://erj.ersjournals.com/content/43/5/1472.abstract N2 - Latent infection with Mycobacterium tuberculosis (LTBI) is defined by the presence of M. tuberculosis-specific immunity in the absence of active tuberculosis. LTBI is detected using interferon-γ release assays (IGRAs) or the tuberculin-skin-test (TST). In clinical practice, IGRAs and the TSTs have failed to distinguish between active tuberculosis and LTBI and their predictive value to identify individuals at risk for the future development of tuberculosis is limited. There is an urgent need to identify biomarkers that improve the clinical performance of current immunodiagnostic methods for tuberculosis prevention, diagnosis and treatment monitoring. Here, we review the landscape of potential alternative biomarkers useful for detection of infection with M. tuberculosis. We describe what individual markers add in terms of specificity for active/latent infection, prediction of progression to active tuberculosis and immunodiagnostic potential in high-risk groups' such as HIV-infected individuals and children. The field of biomarkers for the guidance of clinical management of patients with tuberculosis is rapidly evolving http://ow.ly/r2Ep2 ER -