TY - JOUR T1 - <em>APOM</em> and high-density lipoprotein cholesterol are associated with lung function and per cent emphysema JF - European Respiratory Journal JO - Eur Respir J SP - 1003 LP - 1017 DO - 10.1183/09031936.00147612 VL - 43 IS - 4 AU - Kristin M. Burkart AU - Ani Manichaikul AU - Jemma B. Wilk AU - Firas S. Ahmed AU - Gregory L. Burke AU - Paul Enright AU - Nadia N. Hansel AU - Demondes Haynes AU - Susan R. Heckbert AU - Eric A. Hoffman AU - Joel D. Kaufman AU - Jun Kurai AU - Laura Loehr AU - Stephanie J. London AU - Yang Meng AU - George T. O’Connor AU - Elizabeth Oelsner AU - Marcy Petrini AU - Tess D. Pottinger AU - Charles A. Powell AU - Susan Redline AU - Jerome I. Rotter AU - Lewis J. Smith AU - María Soler Artigas AU - Martin D. Tobin AU - Michael Y. Tsai AU - Karol Watson AU - Wendy White AU - Taylor R. Young AU - Stephen S. Rich AU - R. Graham Barr Y1 - 2014/04/01 UR - http://erj.ersjournals.com/content/43/4/1003.abstract N2 - Chronic obstructive pulmonary disease (COPD) is linked to cardiovascular disease; however, there are few studies on the associations of cardiovascular genes with COPD. We assessed the association of lung function with 2100 genes selected for cardiovascular diseases among 20 077 European-Americans and 6900 African-Americans. We performed replication of significant loci in the other racial group and an independent consortium of Europeans, tested the associations of significant loci with per cent emphysema and examined gene expression in an independent sample. We then tested the association of a related lipid biomarker with forced expiratory volume in 1 s (FEV1)/forced vital capacity (FVC) ratio and per cent emphysema. We identified one new polymorphism for FEV1/FVC (rs805301) in European-Americans (p=1.3×10−6) and a second (rs707974) in the combined European-American and African-American analysis (p=1.38×10−7). Both single-nucleotide polymorphisms (SNPs) flank the gene for apolipoprotein M (APOM), a component of high-density lipoprotein (HDL) cholesterol. Both were replicated in an independent cohort. SNPs in a second gene related to apolipoprotein M and HDL, PCSK9, were associated with FEV1/FVC ratio among African-Americans. rs707974 was associated with per cent emphysema among European-Americans and African-Americans and APOM expression was related to FEV1/FVC ratio and per cent emphysema. Higher HDL levels were associated with lower FEV1/FVC ratio and greater per cent emphysema. These findings suggest a novel role for the apolipoprotein M/HDL pathway in the pathogenesis of COPD and emphysema. Findings from this study suggest a novel effect of the APOM/HDL pathway in the pathogenesis of COPD and emphysema http://ow.ly/t8Ao9 ER -