RT Journal Article
SR Electronic
T1 Plasma advanced glycation end-products and skin autofluorescence are increased in COPD
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP 430
OP 438
DO 10.1183/09031936.00135312
VO 43
IS 2
A1 Poornima Gopal
A1 Niki L. Reynaert
A1 Jean L.J.M. Scheijen
A1 Lean Engelen
A1 Casper G. Schalkwijk
A1 Frits M.E. Franssen
A1 Emiel F.M. Wouters
A1 Erica P.A. Rutten
YR 2014
UL http://erj.ersjournals.com/content/43/2/430.abstract
AB Chronic obstructive pulmonary disease (COPD) is associated with systemic inflammation and oxidative stress. These conditions may lead to the formation of advanced glycation end-products (AGEs). In this study we investigated in 88 COPD patients and 55 control subjects (80% ex-smokers) the association of the plasma protein-bound AGEs Nϵ-(carboxymethyl)lysine (CML), pentosidine, Nϵ-(carboxyethyl)lysine (CEL), and AGE accumulation in skin by skin autofluorescence (AFR), with lung function. Mean±sd plasma CML was decreased (COPD 61.6±15.6 nmol·mmol−1 lysine, never-smokers 80.7±19.8 nmol·mmol−1 lysine and ex-smokers 82.9±19.3 nmol·mmol−1 lysine) and CEL (COPD 39.1±10.9 nmol·mmol−1 lysine, never-smokers 30.4±5.0 nmol·mmol−1 lysine and ex-smokers 27.7±6.4 nmol·mmol−1 lysine) and AFR (COPD 3.33±0.67 arbitrary units (AU), never-smokers 2.24±0.45 AU and ex-smokers 2.31±0.47 AU) were increased in COPD patients compared to controls. Disease state was inversely associated with CML, and linearly associated with CEL and AFR. Performing regression analyses in the total group, CEL and AFR showed a negative association and CML a positive association with lung function, even after correction for potential confounders. In conclusion, CEL and AFR were negatively and CML was positively associated with disease state. In the total group only the AGEs showed an association with forced expiratory volume in 1 s. Our data suggest that AGEs are involved in the pathophysiology of COPD, although their exact role remains to be determined. Advanced glycation end-products are involved in the pathophysiology of COPD, but their exact role remains unknown http://ow.ly/r2wBR