@article {Boschettop574, author = {Piera Boschetto and Barbara Bottazzi and Alessandro Fucili and Alfredo Potena and Licia Ballerin and Mariarita Stendardo and Simonetta Piva and Alessia Verduri and Bianca Begh{\'e} and Alberto Mantovani and Leonardo Fabbri and Roberto Ferrari and Claudio Ceconi}, title = {Interleukin-6, but not pentraxin 3, predicts adverse clinical outcomes on short-term prognosis of patients with incipient heart failure}, volume = {38}, number = {Suppl 55}, elocation-id = {p574}, year = {2011}, publisher = {European Respiratory Society}, abstract = {We investigated the clinical significance of plasma interleukin (IL)-6, IL-1, IL-1 decoy receptor and pentraxin 3 (PTX3) levels in chronic heart failure (CHF) patients with or without chronic obstructive pulmonary disease (COPD). Plasma levels of these inflammatory markers were measured by using a sandwich enzyme-linked immunosorbent assay in 118 patients. Subjects were >=65 years, >=10 pack-years, with a new diagnosis of CHF. The prevalence of COPD was 30\% (36/118). Only 2/118 patients had previously diagnosed COPD. The percent of patients given β-blockers (80\% vs 89\%, P = 0.1), and the optimized to CHF target dose of β-blockers (46.3\% vs 59.7\%, P = 0.1) were no different in patients with or without COPD. Subjects were prospectively followed for 357 (336-364) days with the end point of death or all-cause hospitalization (adverse event). Baseline plasma levels of IL-6, IL-1, IL-1 decoy receptor and PTX3 were comparable between CHF patients with and without COPD. None of the inflammatory markers correlated with CHF severity. Death or hospitalization occurred in 70 (59.3\%) patients. High IL-6 levels was a significant independent predictor for adverse event (WALD CHI-SQUARE P=0.0083), whereas IL-1, IL-1 decoy receptor and PTX3 were not. IL-6 levels correlated positively with high-sensitive C-reactive protein (hs-CRP) levels (r = 0.67, p \< 0.0001), although hs-CRP was not associated with death or hospitalization.These results suggest that plasma levels of IL-6 might serve as a prognostic markers in short-term prognosis of elderly CHF patients either with or without COPD.}, issn = {0903-1936}, URL = {https://erj.ersjournals.com/content/38/Suppl_55/p574}, eprint = {https://erj.ersjournals.com/content}, journal = {European Respiratory Journal} }