PT  - JOURNAL ARTICLE
AU  - Mihaela Coliba
AU  - Alexandru Corlateanu
AU  - Victor Botnaru
TI  - Gender differences of predictors of health status in patients with COPD
DP  - 2011 Sep 01
TA  - European Respiratory Journal
PG  - p545
VI  - 38
IP  - Suppl 55
4099  - http://erj.ersjournals.com/content/38/Suppl_55/p545.short
4100  - http://erj.ersjournals.com/content/38/Suppl_55/p545.full
SO  - Eur Respir J2011 Sep 01; 38
AB  - Background: In recent years there has been an increase in the incidence, prevalence and mortality of COPD in women. The influence of gender on the health status of COPD patients is studied rather superficially.The aim of the study was to to evaluate the health status of COPD patients and to identify the main predictors of quality of life in these patients according to the gender.Methods: 80 consecutive COPD patients were enrolled into the study. Spirometric data were analyzed (FEV1, FVC, FEV1/FVC) and BODE index (BMI, FEV1, MRC, 6 MWD). Health-related quality of life was assessed by the Clinical COPD Questionnaire (CCQ) and the St. George Respiratory Questionnaire (SGRQ).Results: The cohort consisted of 40 women with mean age 65±8.3 years and 40 men with mean age 64±8 years. Patients in both groups had the similar severity of COPD by GOLD/ATS/ERS: FEV1,% was 46.27±15% versus 44.9±9.5% (p= 0.62). Patients in both groups had similar scores of all domains of the SGRQ: total 62.23 vs 65.01, p= 0.29; symptoms 76.46 vs 80.63, p=0.29; activity 57.49 vs 59.35, p=0.58; impact 60.49 vs 63.35, p=0.29. There were no significant differences in CCQ total score 2.96 vs 2.8, p=0.38. The forward stepwise regression analysis shows that the BODE index, severity of obstruction and comorbidities are the important predictors of health related quality of life in men, which explain 55% of the total score of SGRQ (p<0.01). In women, 6MWD, age and oxygenation explain 54.6% of SGRQ total score.Conclusion: BODE index, degree of obstruction and comorbidities were found to be the major determinats of quality of life in men, meanwhile age, exercise capacity and level of arterial oxygenation in women.