TY - JOUR T1 - Combined endoscopic evaluation of the effectiveness of neoadjuvant chemotherapy of NSCLC using autofluorescence and spectroscopic methods JF - European Respiratory Journal JO - Eur Respir J VL - 38 IS - Suppl 55 SP - p3692 AU - Yulia Kulakova AU - Andrey Arsenev AU - Evgeniy Levchenko AU - Alexey Barchuk AU - Andrey Akopov Y1 - 2011/09/01 UR - http://erj.ersjournals.com/content/38/Suppl_55/p3692.abstract N2 - Objectives: To estimate the informativity of autofluorescence bronchoscopy and spectroscopy for evaluating the effectiveness of neoadjuvant chemotherapy (NCT) for lung cancer.Material and methods: The study included 46 patients with central NSCLC IIIa/IIIb stage who underwent 2-4 courses of platinum-based NCT. Endoscopy was done before treatment started and repeated each 21 day. Combined endoscopic investigation included: bronchoscopy in conventional mode (CB), spectroscopy in conventional mode (CS), bronchoscopy in autofluorescence mode (AFB) and spectroscopy in autofluorescence mode (AFS). Integrated system for autofluorescence and spectroscopy ClearVu Elite (Perceptronix Med. Inc., Canada) was used. The data obtained were compared with the results of histological study of biopsy samples from the respective sites.Results: The sensitivity and specificity of the combination of AFB and AFS was 97.1% and 88.3%, respectively vs. CB and CS - 66,7% and 86,9%, respectively. Combined endoscopy revealed that the NCT was effective in 41,3% cases (n = 19 - partial endoscopic response), in 4 patients (10,3%) endoscopic tumor progression was found. Endobronchial spread of the tumor in 30.4% of cases (p = 0.03) was defined more accurately by AFB and AFS in comparison with CB and CS, it was important for choosing a volume of further resection. In 97,1% of cases, the data AFB and AFS is fully consistent with the results of histological studies (p = 0,02).Conclusions: The combination of AFB and AFS is effective in determination of margins of central lung cancer spread and effectiveness of NCT. ER -