PT - JOURNAL ARTICLE AU - Astrid Sevelsted AU - Hans Bisgaard TI - Peri-natal weight gain and early development of recurrent wheeze and asthma in term children DP - 2011 Sep 01 TA - European Respiratory Journal PG - p4261 VI - 38 IP - Suppl 55 4099 - http://erj.ersjournals.com/content/38/Suppl_55/p4261.short 4100 - http://erj.ersjournals.com/content/38/Suppl_55/p4261.full SO - Eur Respir J2011 Sep 01; 38 AB - Rationale: Peri-natal growth and asthma may share originsObjectives: We explored the association between growth in the peri-natal period and the development of recurrent wheeze and asthma.Methods: The analysis included 398 of a birth cohort of 411 Danish neonates born at term of mothers with a history of asthma. The primary end-points were recurrent wheeze and asthma. Atopic dermatitis was also investigated. Algorithm-diagnoses were based on 6-monthly clinical examinations and at acute episodes in a prospective, single-center, birth cohort study.Measurements and main results: Birth weight and length and infant growth rate were estimated from the linear regression of z-scores measured at four occasions during the first year of life. Risk was estimated from Cox and logistic regression analysis. Multivariate models were adjusted for gender, gestational age, mothers smoking during pregnancy, and duration of exclusive breastfeeding.Weight at birth (Z-score) was associated with development of recurrent wheeze and asthma with an adjusted hazard ratio of 1.277 95%CI:[1.025;1.591] (p=.029), while increased growth in infant weight was associated with an adjusted hazard ratio of 1.145 95%CI:[0.997;1.316] (p=.055). Analyses of length and BMI at birth and growth of those showed comparable effects. There were no association between infant size or growth rate and the development of atopic dermatitis.Conclusions: Weight gain in the peri-natal period was significantly associated with the development of recurrent wheeze or asthma in young at-risk children born at term suggesting peri-natal mechanisms as a common link.