RT Journal Article SR Electronic T1 Association of weight loss in COPD patients with low body mass index on outcomes JF European Respiratory Journal JO Eur Respir J FD European Respiratory Society SP p3487 VO 38 IS Suppl 55 A1 Erica Rutten A1 Richard Casaburi A1 Michael Watkins A1 Nicolas Locantore A1 Emiel Wouters YR 2011 UL http://erj.ersjournals.com/content/38/Suppl_55/p3487.abstract AB The impact of COPD phenotypes based on body composition and it's change was evaluated on longitudinal outcomes in COPD patients from the “Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints” (ECLIPSE) study.We assessed the effect of low body mass index (BMI) (BMI <21 kg/m2) at Study Year 1 for 364 COPD patients and assessed the impact of BMI and the change in BMI from baseline to year 1 on mortality during the subsequent two years of the study. During the follow-up, there were 31 deaths. Using logistic regression, each decrease from baseline to Year 1of 1 kg/m2 in BMI in this underweight group was associated with a 51% increased risk of death after controlling for FEV1% predicted and BMI.View this table:Logistic Regression with mortality during Year 2 and Year 3 as dependent variable in underweight subjectsThese findings suggest that for a group of underweight COPD patients, the magnitude of weight change in the previous year is an independent predictor of poor outcome.Funded by GlaxoSmithKline (SCO104960, NCT00292552).