TY - JOUR T1 - Effect of nanoparticle and NO<sub>2</sub> exposure on thoracic gas volume in Brown Norway rat JF - European Respiratory Journal JO - Eur Respir J VL - 38 IS - Suppl 55 SP - p4597 AU - Skander Layachi AU - Françoise Rogerieux AU - Christelle Gamez AU - Kelly Blazy AU - Franck Robidel AU - Anthony Lecomte AU - Ghislaine Lacroix AU - Sam Bayat Y1 - 2011/09/01 UR - http://erj.ersjournals.com/content/38/Suppl_55/p4597.abstract N2 - Rationale: Air pollutant exposure, has been associated with increased asthma morbidity in children. The aim of the present study was to determine whether exposure to NO2 and carbon nanoparticles (CNP) affect the rate of Thoracic gas volume (TGV) change with growth in 7-week old Brown-Norway (BN) rats.Methods: Animals were anesthetized and tracheally intubated. TGV was measured using whole-body plethysmography at age 49 days, and following a 4-wk exposure to air, NO2 (10 ppm) 5h/d, 5d/wk, CNP (FW2, Ø13 nm; 3 instillations at 7-day intervals), or CNP+NO2. Serum cytokines were quantified using multi-array immunoassay.Results: TGV significantly increased after 4 weeks in all groups. When normalized to body weight, TGV increased significantly only in the air-exposed group.View this table:Conclusions: These data show that a 4-wk exposure to either NO2 or CNP significantly decreases TGV and the rate of TGV increase with age in BN rat, suggesting a reduced lung growth rate. CNP, NO2 and combined exposure produced distinct lung inflammatory cytokine profiles. ER -