TY - JOUR T1 - Immune status in patients with bronchial asthma exacerbation and comorbide digestive system diseases JF - European Respiratory Journal JO - Eur Respir J VL - 38 IS - Suppl 55 SP - p3845 AU - Shamil Zagidullin AU - Elena Galimova AU - Guzel Nurtdinova AU - Rustem Zulkarneev Y1 - 2011/09/01 UR - http://erj.ersjournals.com/content/38/Suppl_55/p3845.abstract N2 - Bronchial asthma (BA) is frequently linked with digestive system pathologyAim: To evaluate features of immune status in bronchial asthma (BA) patients with and without comorbide digestive system diseases (DSD).Materials and methods: Prospective, descriptive study of 90 hospitalized patients with bronchial asthma exacerbation and 31 healthy controls. Immune status was assessed via quantitation of lymphocytes subpopulations, immunoglobulins A,E,G,M, circulating immune complexes. Digestive system diseases were diagnosed via gastroscopy and ultrasonic scanning.Results: 61 (67,8%) patients with BA exacerbation suffered from digestive system diseases:gastritis, duodenitis-27 patients (30,0%), duodenum anabrosis-4 (4,5%), gastric-duodenum reflux-20 (22,2%), biliary dyskinesia-10 (11,1%).Immune response parameters were decreased in both groups of BA patients vs. controls.View this table:Immune status in patients with BA±DSDPatients with BA and DSD showed significant decrease of CD4, CD8 and IgA vs. controls and patients with BA without comorbidities.Conclusions: Comorbide digestive system diseases in patients with BA are associated with significant decrease of activity of cell and humoral parts of immune system. ER -