TY - JOUR T1 - Clinical and epidemiological patterns of pediatric patients with mycobacterial disease at the TB reference centre in Milan JF - European Respiratory Journal JO - Eur Respir J VL - 38 IS - Suppl 55 SP - p4974 AU - TAlice Repossi AU - Monica Delmastro AU - Maurizio Ferrarese AU - Rita Lipreri AU - Giovanni Ferrara AU - Luigi Codecasa Y1 - 2011/09/01 UR - http://erj.ersjournals.com/content/38/Suppl_55/p4974.abstract N2 - As in adults, occurrence of children TB has became quite rare in the last decades in Italy. We report a survey of 269 consecutive cases of mycobacterial disease (MD) in subjects under 18 yrs of age. diagnosed or referred to the Regional TB Ref Centre from 2000 to 2010.Results: 139 were M, 130 F, 113 were Italians, 156 immigrants, 135 < 5 yrs and 58 >14 yrs.157 had an intra-thoracic disease, 91 extra-thoracic e 21 both. Among thoracic disease lungs were involved in 97 pts, hilar-mediastinal lymph nodes in 92, and pleura in 11. Of the extra-thoracic forms, 85 were in neck lymp nodes, 9 in other lymp nodes, 8 were abdominal (peritoneal, mesenteric etc), 5 were bone disease, 3 skin, 1 genital, 1 urologic.In 95 a microbiological confirmation was obtained: MT 55 pts, NTM 40 pts. In all other acses diagnosis was based on demographic and clinical aspects, history of contact with TB cases, histological results or immunologic tests (IGRA/TST).Of the isolated NTM 25 were M. avium, 3 M.intracellulare, 2 M. scrofulaceum, 1 M. fortuitum, 1 M. malmoensis, 1 M. Haemofilum, 1 M. Kansasii, 1 M. Xenopi, 1 M. Lentiflavum e 4 M. could not be identified.Medical, surgical or combined therapy guaranteed success in 239 pts, 2 had to stop treatment for adverse events,% were transferred to other centres, 3 were lost to follow up and 20 are still under treatment. ER -