PT - JOURNAL ARTICLE AU - Tanja Pavlovic AU - Ljudmila Nagorni AU - Marija Mitic Milikic AU - Dejan Pavlovic TI - Passive smoking may influence respiratory allergic reaction DP - 2011 Sep 01 TA - European Respiratory Journal PG - p4086 VI - 38 IP - Suppl 55 4099 - http://erj.ersjournals.com/content/38/Suppl_55/p4086.short 4100 - http://erj.ersjournals.com/content/38/Suppl_55/p4086.full SO - Eur Respir J2011 Sep 01; 38 AB - It has been proven that smoking boosts the symptoms of allergy; the smokers have higher bronchial responsiveness and tobacco smoking provokes a strong immunological imbalance to those exposed.The aim of our study was to evaluate reactivity and sensitivity of respiratory tract in persons with the symptoms of allergic rhinitis and proven tobacco smoke allergy who are active smokers or passively exposed to tobacco smoke.Materials and methods: We evaluated 40 patients, average age 34 years divided into two groups: group I - active smokers (with average 16.4±8.7 package years) and group II – passive smokers. All subjects had symptoms of allergic rhinitis, local ORL findings that confirms excluded vasomotor rhinitis, positive Prick test on inhalation allergens of tobacco smoke and normal basal spirometry findings. Non-specific bronchoprovocative testing was done by intermittent inhalation of histamine in progressive grooving doze and result was expressed by the value of provocative doze by which the value of FEV1 was reduced by 20% of basal FEV1. Histamine responsiveness was analyzed using dose-response slope to describe each subject's responsiveness (positive results were considered to be if reactivity was between 520-2000mcg).Results: Bronchial activity was confirmed in 58.2% in smoking group and 39.5% in non-smoking group. The degree of bronchial hypereactivity didn't differ between groups, although provocative doze was in lower concentrations in smoking group, but difference wasn't significant.Conclusion: Although we confirmed that smokers have higher degree of hypereactivity than non-smokers, our results in passive smokers group may implicate on significance of passive smoking.