RT Journal Article SR Electronic T1 Bone mineral density in patients with COPD depending on pulmonary function parameters JF European Respiratory Journal JO Eur Respir J FD European Respiratory Society SP p3595 VO 38 IS Suppl 55 A1 Olga Kharevich A1 Irina Lapteva A1 Artem Tomashevsky A1 Natalia Porahonko A1 Natalia Vasilieva A1 Volha Vadzianava YR 2011 UL http://erj.ersjournals.com/content/38/Suppl_55/p3595.abstract AB Introduction: Osteoporosis is one of the most serious systemic effects of chronic obstructive pulmonary disease (COPD), which has serious consequences and significant impact on mortality, social and economic burden.Aims and objectives: The aim of the study was to investigate the relations between pulmonary function parameters and bone mineral density (BMD) in patients with COPD.Methods: In the recent research we have studied data of pulmonary function tests (by spirometry, bodyplethysmography, diffusing lung capacity) and BMD measurements by dual-energy X-ray absorptiometry in 24 patients with COPD. To compare BMD values in patients with FEV1< 50% and those with FEV1>50%, we used the Mann-Whitney test. Correlations were estimated by Spearman coefficient. Data are presented as median (interquartile range).Results: There were significant differences between BMD values (T-score) in patients with FEV1<50% (n=14, female-1, males-13, median age 56,5 [51; 61]) and those with FEV1>50% (n=10, females-3, males-7, median age 56,0 [54; 58]) in lumbar spine (-1,7 [-2,4; 0,3] versus -0,3 [-0,6; 1,0], p=0,04) and in femoral neck (-1,7 [-2,6; -0,4] versus -0,5 [-0,7; -0,3], p=0,043). Correlation analysis revealed relations between BMD values and residual lung volume (Neck: r = -0,808, p = 0,005; Upper Neck: r = -0,697, p = 0,025; Total: r = -0,683, p = 0,029), ratio of residual lung volume to total lung capacity (Neck: r = -0,722, p = 0,018), diffusing lung capacity (Neck: r = 0,597, p = 0,039).Conclusion: The results of the study confirm the role of lung function reduction in bone loss and osteoporosis development in patients with COPD.