@article {Balfep2135, author = {David Balfe and Zab Mosenifar}, title = {Improved survival with increased IC/TLC ratio, DLCO and FEV1 in an analysis of a COPD pulmonary function database}, volume = {38}, number = {Suppl 55}, elocation-id = {p2135}, year = {2011}, publisher = {European Respiratory Society}, abstract = {Introduction: COPD is the fourth leading cause of death worldwide. FEV1 is predictive of COPD mortality. The IC/TLC is a measure of static lung hyperinflation.Aims: Analysis of a pulmonary function (PF) database evaluating the influence of FEV1, DLCO, IC/TLC and other variables on survival.Design: Retrospective analysis of PF data base (31 year). 984 PF{\textquoteright}s with a reduced FEV1/FVC, increased TLC and reduced DLCO were analyzed. The date of initial PF test was used as the initiation of the survival analysis. 596 subjects had dates of death. Kaplan-Meier survival plots, in addition to Cox analysis was performed to evaluate the relationship of age, FEV1 (GOLD stage), DLCO and IC/TLC ratio on survival, in addition multivariate analyses was performed assessing the effects of age, FEV1, gender, DLCO and BMI with the IC/TLC ratio.Results: Cox analysis for the risk of death, revealed that a reduced IC/TLC ratio (<= 25\%) [HR 1.69, p\<0.0001]; low DLCO (\<22\% predicted) [HR 1.28, p0.043); increased age [HR 1.035 for 5 year increase, p \<0.0001] predicted death. Female gender [HR 0.692, p0.692) and increased FEV1 (mild vs moderate) is predictive of survival [HR 0.69, p 0.0089]. Multivariate analysis revealed that age, gender, and IC/TLC (absolute ratio) remained the only statistically significant independent predictors of survival (HR= 1.04, 95\% CI: 1.03-1.04; HR 0.69, 95\% CI: 0.60-0.83; HR 1.69, 95\% CI: 1.34-2.13, respectively).Conclusion: Analysis of a PF database reveals statistically significant associations of a number of measured and demographic variables with survival. IC/TLC ratio \> 25\%, DLCO >= 22\%, Mild FEV1, Female gender, and BMI \>25 is associated with survival.}, issn = {0903-1936}, URL = {https://erj.ersjournals.com/content/38/Suppl_55/p2135}, eprint = {https://erj.ersjournals.com/content}, journal = {European Respiratory Journal} }