TY - JOUR T1 - Comparison of different vasodilators in a model of secondary pulmonary hypertension (PH): Desaturation effects JF - European Respiratory Journal JO - Eur Respir J VL - 38 IS - Suppl 55 SP - p2291 AU - Eva Maria Becker AU - Johannes-Peter Stasch AU - Martin Bechem AU - Raimund Kast AU - Hubert Truebel Y1 - 2011/09/01 UR - http://erj.ersjournals.com/content/38/Suppl_55/p2291.abstract N2 - Approved therapies for arterial PH when applied in secondary forms can cause desaturation. Therefore we established an animal model to evaluate PH-therapeutics under experimental conditions of heterogeneous lung injury in respect to oxygenation.Single-lung ventilation was induced in minipigs (4-5 kg BW). Hemodynamics (e.g. mean pulmonary artery pressure (mPAP), blood pressure (BP)) and arterial hemoglobin saturation (SaO2) were monitored. We compared 5 groups (n=6 each): vehicle control, the endothelin antagonist bosentan, the PDE5 inhibitor sildenafil, and the sGC stimulators BAY 41-8543 and riociguat. Cumulative doses were applied before successive unilateral ventilation, chosen to achieve equal BP reduction. Effects on desaturation (area under the SaO2 curve, AUCSaO2) and mPAP during single-lung ventilation were compared to vehicle.Single-lung ventilation resulted in transient increases in mPAP and desaturation. The vasodilators were compared in respect to their ability to decrease mPAP and the unwanted increase in AUCSaO2. All drugs dose-dependently decreased mPAP (Fig. 1) and increased AUCSaO2. Maximal changes in both parameters are shown in Fig. 2 (meanĀ±SEM, n=6).The sGC stimulators and bosentan effectively reduced mPAP; the sGC stimulators caused less desaturation. Future investigations will have to confirm these findings in patients. ER -