TY - JOUR T1 - Chest wall kinematics during different levels of positive end-expiratory pressure in cystic fibrosis children JF - European Respiratory Journal JO - Eur Respir J VL - 38 IS - Suppl 55 SP - p2106 AU - Guilherme Augusto de Freitas Fregonezi AU - Silvia Brilhante AU - Melissa Gurgel AU - Rencio Florencio AU - Karen Soares AU - Fernando Augustos Lavezzo Dias AU - Vanessa Resqueti AU - Armele de Fátima Dornelas de Andrade Y1 - 2011/09/01 UR - http://erj.ersjournals.com/content/38/Suppl_55/p2106.abstract N2 - Objective: To study the effects of different levels of positive end expiratory pressure (PEEP) on compartmental chest volumes.Methods: Twelve patients with CF (12±2.7 years; FEV1/FVC%:81.3%±6.6 and FEV1%:69±12) and ten age-matched healthy subjects (control group-CG); 11±1.8 years) with normal lung function. Both groups were evaluated by Optoelectronic Plethysmography in 3 minutes of quite breathing (QB), 3 minutes breathing against 3 levels of PEEP, 10 cmH2O, 15 cmH2O and 20 cmH2O.Results: Both groups were similar during QB. Intergroup analyses shown that tidal volume of chest wall was different between CF and CG at PEEP10 (Vtcw=0.486±0.180L vs 0.920±0.500L,p=0.0236; respectively) and at PEEP20 (Vtcw=0.511±0.170L vs. 0.996±0.430L, p=0.0005; respectively). We found differences in respiratory rate between groups at PEEP15 (RR=42.1±17.1 bpm vs RR= 22±6.74,p=0.006), and PEEP20 (RR=37.2±19.3 vs 20.3±8.17,p=0.034). CF intragroup analyses shown that Vtcw increased significantly in all levels of PEEP compared to QB (Vtcw=0.286±0.079L vs PEEP10= 0.487±0.181L vs PEEP15=0.515±0.21L and PEEP20=0.512±0.177L, p<0.001), but no differences were found between PEEPs levels. End expiratory lung volume increase in CF group during PEEP20 in comparison to QB (Veecw=10.2±3.24L vs 10.7±3.58L, p<0.001), end inspiratory lung volume increase in all levels of PEEP when compared to QB (Veicw=10.5±3.26L vs PEEP10=11±3.46L, PEEP15=11±3.49L and PEEP20=11.2±3.6L, p<0.05).Conclusion: The use of PEEP10 and PEEP20 induced different changes in chest wall volumes in CF and CG. All levels of PEEPs improve chest wall volumes in CF children's. ER -