TY - JOUR T1 - CPAP setting prediction in OSAS patients JF - European Respiratory Journal JO - Eur Respir J VL - 38 IS - Suppl 55 SP - p2212 AU - Nikolaos Chavouzis AU - Katalin Fekete Passa AU - Afroditi Boutou AU - Chrysanthi Nakou AU - Asimina Paspala AU - Ioannis Stanopoulos AU - Georgia Pitsiou AU - Athanasia Pataka AU - Vasilios Bagalas AU - Paraskevi Argyropoulou Y1 - 2011/09/01 UR - http://erj.ersjournals.com/content/38/Suppl_55/p2212.abstract N2 - Aim: To determine how well anthropometric measures and data derived from a diagnostic polysomnography (PSG) study predict the CPAP setting required for therapy.Method: Data of 158 women and 592 men who had a diagnostic overnight PSG study, a diagnosis of OSAS (Apnea-Hypopnea Index (AHI) >5 and daytime somnolence) and a CPAP titration study were retrospectively analysed. Regression analysis was used to assess the predictive value of age, height, weight, neck, waist and hip circumferences, systolic and diastolic blood pressure at rest and diagnostic PSG data AHI, desaturation index, minimum (min) saturation, average saturation, average apnea-hypopnea duration for determining the required CPAP therapy pressure setting.Results: Backward regression analysis identified AHI, neck circunference and min saturation as predective parameters for the CPAP pressure. Age and BMI were entered at Step 1 hierarchical regression, explaining 6,1% of the variance in CPAP setting. After entry of AHI, neck circumference and min saturation at Step 2 the total variance explained by the model as a whole was 19,5%, F(5,697) = 35,08, p<0,0005. The three control variables explained an additional 13,8% of the variance in CPAP therapy pressure, after controlling for age and BMI, Fchange(3,697) = 40,06, p<0,0005. In the final model only the three control variables were statistically significant, with AHI achieving the highest beta value (beta=0,24 p<0,0005), then neck circumference (beta=0,17 p<0,0005) and finally min saturation (beta=-0,14 p=0,001).Conclusions: OSAS severity, neck circumference and overnight minimum saturation have a statistically significant contribution of 19,5% on the variance of the CPAP therapy pressure, indipendently of the age and the obesity of the subject. ER -