RT Journal Article
SR Electronic
T1 Double blind, placebo controlled crossover study in COPD patients to assess the acute effect of budesonide/formoterol using HRCT and lung function tests
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP p3362
VO 38
IS Suppl 55
A1 Lieve De Backer
A1 Jan De Backer
A1 Wim Vos
A1 Cedric Van Holsbeke
A1 Samir Vinchurkar
A1 Wilfried De Backer
YR 2011
UL http://erj.ersjournals.com/content/38/Suppl_55/p3362.abstract
AB The aim of this study was to assess the acute effect of inhalation of budesonide/formoterol combination and placebo using lung function tests and imaging in COPD patients and to compare both. A total of 10 patients was assessed in a double blind cross over study. Airway volumes were analysed using segmentation of the HRCT images. Results showed that distal airway volume significantly increased in patients four hours after receiving budesonide/formoterol combination. No other lung function parameters showed a significant change. When considering the effect of placebo a significant decline in distal airway volume and peak expiratory flow was observed. A downward trend was depicted by forced expiratory volume in one second. The bodyplethysmography showed a significant increase in specific airway resistance. In addition it was shown that imaging was the only parameter that was able to predict correctly the visit at which the combination product was administered for all patients.This study showed that imaging is a sensitive, complementary tool to describe changes in airway structure and function. Future uses could include the assessment of anti-inflammatory compounds as standard lung function test might lack the sensitivity to describe the more subtle changes.